infoResearch Use Only
This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or animal consumption.
Cagrilintide
C194H296N50O60
infoResearch Use Only
This product is intended solely for use as a research chemical in vitro and laboratory experimentation. Not for human use.
Overview
Cagrilintide is a long-acting amylin analog designed to mimic the physiological effects of endogenous amylin, a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. This acylated analog features modifications that extend its pharmacokinetic profile, enabling once-weekly dosing in research applications.
**MECHANISM OF ACTION:** Cagrilintide activates amylin receptors, which are composed of calcitonin receptor complexes with receptor activity-modifying proteins (RAMPs). Amylin receptor activation influences: - Gastric emptying rate through vagal pathways - Glucagon secretion suppression - Satiety signaling in the area postrema - Hepatic glucose output modulation
The acylation modification (C18 fatty diacid) enables albumin binding, dramatically extending plasma half-life compared to native amylin.
**RESEARCH APPLICATIONS:** - Amylin Receptor Signaling Studies - Satiety Pathway Research - Gastric Motility Analysis - Glucagon Regulation Studies - Metabolic Combination Therapy Research - Calcitonin Receptor Family Studies
**CLINICAL DEVELOPMENT:** Cagrilintide is under active investigation in combination with semaglutide (CagriSema) in phase 3 clinical trials. Early data published in The Lancet demonstrated additive metabolic effects when combined with GLP-1 receptor agonists.
**TECHNICAL SPECIFICATIONS:** - Classification: Long-acting amylin analog - Modification: C18 fatty diacid acylation - Half-life: ~7 days (enabling weekly dosing) - Form: Lyophilized powder - Purity: >97% (HPLC)
**QUALITY ASSURANCE:** Third-party tested for identity, purity, and sterility. Certificate of Analysis provided.
FOR RESEARCH USE ONLY. Not for human consumption.
Research Use Only. This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals. It is not approved for human or veterinary use.
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