Methylcobalamin (B12)

Methylcobalamin is the bioactive, methylated form of Vitamin B12 (cobalamin), distinguished from cyanocobalamin by its methyl group attachment rather than a cyanide moiety. This form of B12 is directly utilized in cellular methylation reactions without requiring enzymatic conversion, making it the preferred form for research applications investigating B12-dependent pathways.

**MECHANISM OF ACTION:** Methylcobalamin serves as an essential cofactor for methionine synthase, the enzyme that converts homocysteine to methionine. This reaction is critical for: - Methyl group regeneration from the folate cycle - SAMe (S-adenosylmethionine) production - DNA and RNA methylation - Myelin synthesis and neurological function

As the neurologically active form of B12, methylcobalamin directly participates in nerve tissue repair and maintenance without requiring hepatic conversion.

**RESEARCH APPLICATIONS:** - Methylation Cycle Studies - Homocysteine Metabolism Research - Neurological Function Analysis - DNA Methylation Pattern Studies - Folate Cycle Interaction Research - Neuropathy Mechanism Studies - Erythropoiesis Research

**BIOAVAILABILITY ADVANTAGE:** Unlike cyanocobalamin, methylcobalamin does not require cyanide group removal and subsequent methylation. Research suggests improved tissue retention and direct neurological availability compared to non-methylated forms.

**TECHNICAL SPECIFICATIONS:** - Molecular Formula: C63H91CoN13O14P - Molecular Weight: 1344.38 g/mol - CAS Number: 13422-55-4 - Form: Sterile injectable solution - Appearance: Clear red solution

**QUALITY ASSURANCE:** Third-party tested for potency and sterility. Light-protected packaging.

FOR RESEARCH USE ONLY. Not for human consumption.